M-142 is an east–west state trunkline highway in The Thumb region of the US state of Michigan. It is a “trans-peninsular” highway in that it travels from Bay Port on Saginaw Bay to Harbor Beach on Lake Huron.

M-1, also known as Woodward Avenue, is a north–south state trunkline highway in the Metro Detroit area of Michigan. The highway, called “Detroit’s Main Street”, runs from Detroit north-northwesterly to Pontiac.

M-25 is a state trunkline highway in Michigan. The route follows an arc-like shape closely along the Lake Huron shore of the Thumb in the eastern Lower Peninsula between Port Huron and Bay City. It serves the lakeshore resorts along Lake Huron and Saginaw Bay and generally lies within sight of the lake and the bay.

M-53 is a north–south state trunkline highway in Michigan that connects Detroit to The Thumb region. The highway starts in Detroit at a connection with M-3 and ends in Port Austin at M-25.